Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion

Chenggang Mao; Xiaochun Zhou; Yidao Jiang; Lijia Wan; Zezhang Tao

doi:doi:10.11648/j.jdmp.20190501.12

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Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion

Chenggang Mao, Xiaochun Zhou, Yidao Jiang, Lijia Wan, Zezhang Tao

Published in Journal of Diseases and Medicinal Plants (Volume 5, Issue 1)

Received: 4 January 2019 Accepted: 23 January 2019 Published: 15 February 2019

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Abstract

The dietary compound phenethyl isothiocyanate (PEITC), is an active component of cruciferous vegetables and markedly inhibits the growth of a variety of tumors. However, its role in human nasopharyngeal carcinoma (NPC) is obscure. The aim of the present study was to elucidate the possible mechanisms whereby PEITC exhibited anticancer properties in human nasopharyngeal carcinoma NPC-TW01 cells in vitro. The experiment results exhibited that in a dose- and time-dependent manner treatment of NPC-TW01 cells with PEITC significantly inhibited cell proliferation, promoted apoptosis with concurrent G2/M cell cycle arrest and inhibited cell invasion in a dose-dependent manner. These effects were accompanied by significant alterations in the expression levels of key proteins associated with pro-survival signaling pathways, including PI3K, Akt, ERK, NF-κB, Bcl, Bax, cyclin B, CDK4 and CDK6. Significantly, these effects were not reflected in 16HBE normal human bronchial epithelial cells, indicating a safe range of treatment concentrations between 0 and 10 μM PEITC. In conclusion, PEITC exhibited significant anticancer effects against human nasopharyngeal carcinoma cells in vitro with low toxicological impact on normal bronchial epithelial cells. This was achieved through dysregulation of key proteins involved in the occurrence and development of tumors, and this approach may be applied to the clinical treatment of NPC and in drug screening.

Published in	Journal of Diseases and Medicinal Plants (Volume 5, Issue 1)
DOI	10.11648/j.jdmp.20190501.12
Page(s)	10-16
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Phenethyl Isothiocyanate, Nasopharyngeal Carcinoma, NPC-TW01, Anticancer, Toxicity

References

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APA Style

Chenggang Mao, Xiaochun Zhou, Yidao Jiang, Lijia Wan, Zezhang Tao. (2019). Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion. Journal of Diseases and Medicinal Plants, 5(1), 10-16. https://doi.org/10.11648/j.jdmp.20190501.12

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ACS Style

Chenggang Mao; Xiaochun Zhou; Yidao Jiang; Lijia Wan; Zezhang Tao. Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion. J. Dis. Med. Plants 2019, 5(1), 10-16. doi: 10.11648/j.jdmp.20190501.12

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AMA Style

Chenggang Mao, Xiaochun Zhou, Yidao Jiang, Lijia Wan, Zezhang Tao. Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion. J Dis Med Plants. 2019;5(1):10-16. doi: 10.11648/j.jdmp.20190501.12

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@article{10.11648/j.jdmp.20190501.12,
  author = {Chenggang Mao and Xiaochun Zhou and Yidao Jiang and Lijia Wan and Zezhang Tao},
  title = {Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {5},
  number = {1},
  pages = {10-16},
  doi = {10.11648/j.jdmp.20190501.12},
  url = {https://doi.org/10.11648/j.jdmp.20190501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20190501.12},
  abstract = {The dietary compound phenethyl isothiocyanate (PEITC), is an active component of cruciferous vegetables and markedly inhibits the growth of a variety of tumors. However, its role in human nasopharyngeal carcinoma (NPC) is obscure. The aim of the present study was to elucidate the possible mechanisms whereby PEITC exhibited anticancer properties in human nasopharyngeal carcinoma NPC-TW01 cells in vitro. The experiment results exhibited that in a dose- and time-dependent manner treatment of NPC-TW01 cells with PEITC significantly inhibited cell proliferation, promoted apoptosis with concurrent G2/M cell cycle arrest and inhibited cell invasion in a dose-dependent manner. These effects were accompanied by significant alterations in the expression levels of key proteins associated with pro-survival signaling pathways, including PI3K, Akt, ERK, NF-κB, Bcl, Bax, cyclin B, CDK4 and CDK6. Significantly, these effects were not reflected in 16HBE normal human bronchial epithelial cells, indicating a safe range of treatment concentrations between 0 and 10 μM PEITC. In conclusion, PEITC exhibited significant anticancer effects against human nasopharyngeal carcinoma cells in vitro with low toxicological impact on normal bronchial epithelial cells. This was achieved through dysregulation of key proteins involved in the occurrence and development of tumors, and this approach may be applied to the clinical treatment of NPC and in drug screening.},
 year = {2019}
}

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TY  - JOUR
T1  - Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion
AU  - Chenggang Mao
AU  - Xiaochun Zhou
AU  - Yidao Jiang
AU  - Lijia Wan
AU  - Zezhang Tao
Y1  - 2019/02/15
PY  - 2019
N1  - https://doi.org/10.11648/j.jdmp.20190501.12
DO  - 10.11648/j.jdmp.20190501.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 10
EP  - 16
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20190501.12
AB  - The dietary compound phenethyl isothiocyanate (PEITC), is an active component of cruciferous vegetables and markedly inhibits the growth of a variety of tumors. However, its role in human nasopharyngeal carcinoma (NPC) is obscure. The aim of the present study was to elucidate the possible mechanisms whereby PEITC exhibited anticancer properties in human nasopharyngeal carcinoma NPC-TW01 cells in vitro. The experiment results exhibited that in a dose- and time-dependent manner treatment of NPC-TW01 cells with PEITC significantly inhibited cell proliferation, promoted apoptosis with concurrent G2/M cell cycle arrest and inhibited cell invasion in a dose-dependent manner. These effects were accompanied by significant alterations in the expression levels of key proteins associated with pro-survival signaling pathways, including PI3K, Akt, ERK, NF-κB, Bcl, Bax, cyclin B, CDK4 and CDK6. Significantly, these effects were not reflected in 16HBE normal human bronchial epithelial cells, indicating a safe range of treatment concentrations between 0 and 10 μM PEITC. In conclusion, PEITC exhibited significant anticancer effects against human nasopharyngeal carcinoma cells in vitro with low toxicological impact on normal bronchial epithelial cells. This was achieved through dysregulation of key proteins involved in the occurrence and development of tumors, and this approach may be applied to the clinical treatment of NPC and in drug screening.
VL  - 5
IS  - 1
ER  -

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Author Information

Chenggang Mao

Department of Otolaryngology–Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jinzhou, China
Xiaochun Zhou

Department of Otolaryngology–Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jinzhou, China
Yidao Jiang

Department of Otolaryngology–Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jinzhou, China
Lijia Wan

Department of Otolaryngology–Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jinzhou, China
Zezhang Tao

Department of Otolaryngology–Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China

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APA Style

Chenggang Mao, Xiaochun Zhou, Yidao Jiang, Lijia Wan, Zezhang Tao. (2019). Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion. Journal of Diseases and Medicinal Plants, 5(1), 10-16. https://doi.org/10.11648/j.jdmp.20190501.12

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ACS Style

Chenggang Mao; Xiaochun Zhou; Yidao Jiang; Lijia Wan; Zezhang Tao. Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion. J. Dis. Med. Plants 2019, 5(1), 10-16. doi: 10.11648/j.jdmp.20190501.12

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AMA Style

Chenggang Mao, Xiaochun Zhou, Yidao Jiang, Lijia Wan, Zezhang Tao. Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion. J Dis Med Plants. 2019;5(1):10-16. doi: 10.11648/j.jdmp.20190501.12

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@article{10.11648/j.jdmp.20190501.12,
  author = {Chenggang Mao and Xiaochun Zhou and Yidao Jiang and Lijia Wan and Zezhang Tao},
  title = {Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {5},
  number = {1},
  pages = {10-16},
  doi = {10.11648/j.jdmp.20190501.12},
  url = {https://doi.org/10.11648/j.jdmp.20190501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20190501.12},
  abstract = {The dietary compound phenethyl isothiocyanate (PEITC), is an active component of cruciferous vegetables and markedly inhibits the growth of a variety of tumors. However, its role in human nasopharyngeal carcinoma (NPC) is obscure. The aim of the present study was to elucidate the possible mechanisms whereby PEITC exhibited anticancer properties in human nasopharyngeal carcinoma NPC-TW01 cells in vitro. The experiment results exhibited that in a dose- and time-dependent manner treatment of NPC-TW01 cells with PEITC significantly inhibited cell proliferation, promoted apoptosis with concurrent G2/M cell cycle arrest and inhibited cell invasion in a dose-dependent manner. These effects were accompanied by significant alterations in the expression levels of key proteins associated with pro-survival signaling pathways, including PI3K, Akt, ERK, NF-κB, Bcl, Bax, cyclin B, CDK4 and CDK6. Significantly, these effects were not reflected in 16HBE normal human bronchial epithelial cells, indicating a safe range of treatment concentrations between 0 and 10 μM PEITC. In conclusion, PEITC exhibited significant anticancer effects against human nasopharyngeal carcinoma cells in vitro with low toxicological impact on normal bronchial epithelial cells. This was achieved through dysregulation of key proteins involved in the occurrence and development of tumors, and this approach may be applied to the clinical treatment of NPC and in drug screening.},
 year = {2019}
}

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TY  - JOUR
T1  - Phenethyl Isothiocyanate Inhibits Nasopharyngeal Carcinoma Cell Growth and Invasion
AU  - Chenggang Mao
AU  - Xiaochun Zhou
AU  - Yidao Jiang
AU  - Lijia Wan
AU  - Zezhang Tao
Y1  - 2019/02/15
PY  - 2019
N1  - https://doi.org/10.11648/j.jdmp.20190501.12
DO  - 10.11648/j.jdmp.20190501.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 10
EP  - 16
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20190501.12
AB  - The dietary compound phenethyl isothiocyanate (PEITC), is an active component of cruciferous vegetables and markedly inhibits the growth of a variety of tumors. However, its role in human nasopharyngeal carcinoma (NPC) is obscure. The aim of the present study was to elucidate the possible mechanisms whereby PEITC exhibited anticancer properties in human nasopharyngeal carcinoma NPC-TW01 cells in vitro. The experiment results exhibited that in a dose- and time-dependent manner treatment of NPC-TW01 cells with PEITC significantly inhibited cell proliferation, promoted apoptosis with concurrent G2/M cell cycle arrest and inhibited cell invasion in a dose-dependent manner. These effects were accompanied by significant alterations in the expression levels of key proteins associated with pro-survival signaling pathways, including PI3K, Akt, ERK, NF-κB, Bcl, Bax, cyclin B, CDK4 and CDK6. Significantly, these effects were not reflected in 16HBE normal human bronchial epithelial cells, indicating a safe range of treatment concentrations between 0 and 10 μM PEITC. In conclusion, PEITC exhibited significant anticancer effects against human nasopharyngeal carcinoma cells in vitro with low toxicological impact on normal bronchial epithelial cells. This was achieved through dysregulation of key proteins involved in the occurrence and development of tumors, and this approach may be applied to the clinical treatment of NPC and in drug screening.
VL  - 5
IS  - 1
ER  -

Copy | Download