Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients

Ibrahim Abdulmajeed Altamemi; Alaa Ghani Hussein; Ahmed Raheem Rayshan

doi:doi:10.11648/j.crj.20130103.11

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Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients

Ibrahim Abdulmajeed Altamemi, Alaa Ghani Hussein, Ahmed Raheem Rayshan

Published in Cancer Research Journal (Volume 1, Issue 3)

Received: 13 September 2013 Published: 30 October 2013

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Abstract

Angiogenesis, the formation of new blood vessels from pre-existing ones, is enhanced in various pathological conditions including rheumatoid arthritis, diabetic retinopathy, and cancer development. Angiogenic processes are regulated by both growth factors, such as vascular endothelial growth factor (VEGF), and adhesion molecules, such as integrin. Understanding the molecular mechanisms that underlieregulation of angiogenesis especially VEGF function, is essential for the development of safe and effective antiangiogenic therapies. Thus, current study was aimedto investigate predictive role of β3 integrin and vascular endothelial growth factor (VEGF) protein expression in colorectal adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, andlymph node involvement), by using Immunohistochemicalstaining method. Study done on 35 colorectal cancer samples and their respective resection margins.Present study demonstrated that, the positive expression rate of integrin β3 and VEGF in non-tumorcolorectal mucosa (25.33333 ± 1.974842, and 32.4± 1.974842) was significantly lower than that of the colorectal cancer (CRC)tissue (76.47059± 2.878562, and 79.45714±2.293705; P < 0.05). Moreover, when CRC samples breakdown according to histopathological variables, In patients of stage C-D, poorly differentiated, and withlymph node (L.N)invasion, the positive expression rates of integrin β3 were significantly higher than those in patients of patients with stageA,B, well or moderately differentiated,and without lymphatic metastasis (P < 0.05, P < 0.05, and P < 0.05; P< 0.05, P< 0.05, and P< 0.05), respectively. In conclusion Integrin β3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of colorectal carcinoma. Therefore, they may be prognostic biomarkers and novel molecular therapeutic targets.

Published in	Cancer Research Journal (Volume 1, Issue 3)
DOI	10.11648/j.crj.20130103.11
Page(s)	26-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Colorectal Cancer, Angiogenesis, VEGF

References

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APA Style

Ibrahim Abdulmajeed Altamemi, Alaa Ghani Hussein, Ahmed Raheem Rayshan. (2013). Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients. Cancer Research Journal, 1(3), 26-30. https://doi.org/10.11648/j.crj.20130103.11

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ACS Style

Ibrahim Abdulmajeed Altamemi; Alaa Ghani Hussein; Ahmed Raheem Rayshan. Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients. Cancer Res. J. 2013, 1(3), 26-30. doi: 10.11648/j.crj.20130103.11

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AMA Style

Ibrahim Abdulmajeed Altamemi, Alaa Ghani Hussein, Ahmed Raheem Rayshan. Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients. Cancer Res J. 2013;1(3):26-30. doi: 10.11648/j.crj.20130103.11

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@article{10.11648/j.crj.20130103.11,
  author = {Ibrahim Abdulmajeed Altamemi and Alaa Ghani Hussein and Ahmed Raheem Rayshan},
  title = {Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients},
  journal = {Cancer Research Journal},
  volume = {1},
  number = {3},
  pages = {26-30},
  doi = {10.11648/j.crj.20130103.11},
  url = {https://doi.org/10.11648/j.crj.20130103.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130103.11},
  abstract = {Angiogenesis, the formation of new blood vessels from pre-existing ones, is enhanced in various pathological conditions including rheumatoid arthritis, diabetic retinopathy, and cancer development. Angiogenic processes are regulated by both growth factors, such as vascular endothelial growth factor (VEGF), and adhesion molecules, such as integrin. Understanding the molecular mechanisms that underlieregulation of angiogenesis especially VEGF function, is essential for the development of safe and effective antiangiogenic therapies. Thus, current study was aimedto investigate predictive role of β3 integrin and vascular endothelial growth factor (VEGF) protein expression in colorectal adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, andlymph node involvement), by using Immunohistochemicalstaining method. Study done on 35 colorectal cancer samples and their respective resection margins.Present study demonstrated that, the positive expression rate of integrin β3 and VEGF in non-tumorcolorectal mucosa (25.33333 ± 1.974842, and 32.4± 1.974842) was significantly lower than that of the colorectal cancer (CRC)tissue (76.47059± 2.878562, and 79.45714±2.293705; P < 0.05). Moreover, when CRC samples breakdown according to histopathological variables, In patients of stage C-D, poorly differentiated, and withlymph node (L.N)invasion, the positive expression rates of integrin β3 were significantly higher than those in patients of patients with stageA,B, well or moderately differentiated,and without lymphatic metastasis (P < 0.05, P < 0.05, and P < 0.05; P< 0.05, P< 0.05, and P< 0.05), respectively. In conclusion Integrin β3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of colorectal carcinoma. Therefore, they may be prognostic biomarkers and novel molecular therapeutic targets.},
 year = {2013}
}

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TY  - JOUR
T1  - Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients
AU  - Ibrahim Abdulmajeed Altamemi
AU  - Alaa Ghani Hussein
AU  - Ahmed Raheem Rayshan
Y1  - 2013/10/30
PY  - 2013
N1  - https://doi.org/10.11648/j.crj.20130103.11
DO  - 10.11648/j.crj.20130103.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 26
EP  - 30
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20130103.11
AB  - Angiogenesis, the formation of new blood vessels from pre-existing ones, is enhanced in various pathological conditions including rheumatoid arthritis, diabetic retinopathy, and cancer development. Angiogenic processes are regulated by both growth factors, such as vascular endothelial growth factor (VEGF), and adhesion molecules, such as integrin. Understanding the molecular mechanisms that underlieregulation of angiogenesis especially VEGF function, is essential for the development of safe and effective antiangiogenic therapies. Thus, current study was aimedto investigate predictive role of β3 integrin and vascular endothelial growth factor (VEGF) protein expression in colorectal adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, andlymph node involvement), by using Immunohistochemicalstaining method. Study done on 35 colorectal cancer samples and their respective resection margins.Present study demonstrated that, the positive expression rate of integrin β3 and VEGF in non-tumorcolorectal mucosa (25.33333 ± 1.974842, and 32.4± 1.974842) was significantly lower than that of the colorectal cancer (CRC)tissue (76.47059± 2.878562, and 79.45714±2.293705; P < 0.05). Moreover, when CRC samples breakdown according to histopathological variables, In patients of stage C-D, poorly differentiated, and withlymph node (L.N)invasion, the positive expression rates of integrin β3 were significantly higher than those in patients of patients with stageA,B, well or moderately differentiated,and without lymphatic metastasis (P < 0.05, P < 0.05, and P < 0.05; P< 0.05, P< 0.05, and P< 0.05), respectively. In conclusion Integrin β3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of colorectal carcinoma. Therefore, they may be prognostic biomarkers and novel molecular therapeutic targets.
VL  - 1
IS  - 3
ER  -

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Author Information

Ibrahim Abdulmajeed Altamemi

Deparment of Medical microbiology, College of medicine, Al-Qadisiya University, Alqadisia, Iraq
Alaa Ghani Hussein

Department of Pathology, College of medicine, Alnahrain University, Baghdad, Iraq
Ahmed Raheem Rayshan

Deparment of Pathology, College of medicine, Al-Qadisiya University, Alqadisia, Iraq

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APA Style

Ibrahim Abdulmajeed Altamemi, Alaa Ghani Hussein, Ahmed Raheem Rayshan. (2013). Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients. Cancer Research Journal, 1(3), 26-30. https://doi.org/10.11648/j.crj.20130103.11

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ACS Style

Ibrahim Abdulmajeed Altamemi; Alaa Ghani Hussein; Ahmed Raheem Rayshan. Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients. Cancer Res. J. 2013, 1(3), 26-30. doi: 10.11648/j.crj.20130103.11

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AMA Style

Ibrahim Abdulmajeed Altamemi, Alaa Ghani Hussein, Ahmed Raheem Rayshan. Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients. Cancer Res J. 2013;1(3):26-30. doi: 10.11648/j.crj.20130103.11

Copy | Download

@article{10.11648/j.crj.20130103.11,
  author = {Ibrahim Abdulmajeed Altamemi and Alaa Ghani Hussein and Ahmed Raheem Rayshan},
  title = {Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients},
  journal = {Cancer Research Journal},
  volume = {1},
  number = {3},
  pages = {26-30},
  doi = {10.11648/j.crj.20130103.11},
  url = {https://doi.org/10.11648/j.crj.20130103.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130103.11},
  abstract = {Angiogenesis, the formation of new blood vessels from pre-existing ones, is enhanced in various pathological conditions including rheumatoid arthritis, diabetic retinopathy, and cancer development. Angiogenic processes are regulated by both growth factors, such as vascular endothelial growth factor (VEGF), and adhesion molecules, such as integrin. Understanding the molecular mechanisms that underlieregulation of angiogenesis especially VEGF function, is essential for the development of safe and effective antiangiogenic therapies. Thus, current study was aimedto investigate predictive role of β3 integrin and vascular endothelial growth factor (VEGF) protein expression in colorectal adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, andlymph node involvement), by using Immunohistochemicalstaining method. Study done on 35 colorectal cancer samples and their respective resection margins.Present study demonstrated that, the positive expression rate of integrin β3 and VEGF in non-tumorcolorectal mucosa (25.33333 ± 1.974842, and 32.4± 1.974842) was significantly lower than that of the colorectal cancer (CRC)tissue (76.47059± 2.878562, and 79.45714±2.293705; P < 0.05). Moreover, when CRC samples breakdown according to histopathological variables, In patients of stage C-D, poorly differentiated, and withlymph node (L.N)invasion, the positive expression rates of integrin β3 were significantly higher than those in patients of patients with stageA,B, well or moderately differentiated,and without lymphatic metastasis (P < 0.05, P < 0.05, and P < 0.05; P< 0.05, P< 0.05, and P< 0.05), respectively. In conclusion Integrin β3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of colorectal carcinoma. Therefore, they may be prognostic biomarkers and novel molecular therapeutic targets.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Predictive Role of αVβ3 Integrin, and VEGF in Colorectal Adenocarcinoma Progression in Iraqi Patients
AU  - Ibrahim Abdulmajeed Altamemi
AU  - Alaa Ghani Hussein
AU  - Ahmed Raheem Rayshan
Y1  - 2013/10/30
PY  - 2013
N1  - https://doi.org/10.11648/j.crj.20130103.11
DO  - 10.11648/j.crj.20130103.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 26
EP  - 30
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20130103.11
AB  - Angiogenesis, the formation of new blood vessels from pre-existing ones, is enhanced in various pathological conditions including rheumatoid arthritis, diabetic retinopathy, and cancer development. Angiogenic processes are regulated by both growth factors, such as vascular endothelial growth factor (VEGF), and adhesion molecules, such as integrin. Understanding the molecular mechanisms that underlieregulation of angiogenesis especially VEGF function, is essential for the development of safe and effective antiangiogenic therapies. Thus, current study was aimedto investigate predictive role of β3 integrin and vascular endothelial growth factor (VEGF) protein expression in colorectal adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage, grade, grade, andlymph node involvement), by using Immunohistochemicalstaining method. Study done on 35 colorectal cancer samples and their respective resection margins.Present study demonstrated that, the positive expression rate of integrin β3 and VEGF in non-tumorcolorectal mucosa (25.33333 ± 1.974842, and 32.4± 1.974842) was significantly lower than that of the colorectal cancer (CRC)tissue (76.47059± 2.878562, and 79.45714±2.293705; P < 0.05). Moreover, when CRC samples breakdown according to histopathological variables, In patients of stage C-D, poorly differentiated, and withlymph node (L.N)invasion, the positive expression rates of integrin β3 were significantly higher than those in patients of patients with stageA,B, well or moderately differentiated,and without lymphatic metastasis (P < 0.05, P < 0.05, and P < 0.05; P< 0.05, P< 0.05, and P< 0.05), respectively. In conclusion Integrin β3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of colorectal carcinoma. Therefore, they may be prognostic biomarkers and novel molecular therapeutic targets.
VL  - 1
IS  - 3
ER  -

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