The peculiarities of changes of phenotype properties in MCF-7 human breast cancer cells with different sensitivity to cytostatic agents under the influence of nanoparticles of magnetic fluid were studied. It is defined that the biggest manifestations of magnetic fluid effect both by its essence and direction are observed in cells of resistant MCF-7/Dox line and parental MCF-7/S line in comparison with MCF-7/CP (cisplatin-resistant cell line). In particular, these are more apparent cytotoxic effects and ability to colony-formation, increase of adhesive properties, decrease of invasiveness and proliferative activity, changes of surface charge density and electrokinetic potential as well as lipid composition of cells. The defined differences between MCF-7 cells with different sensitivity to cytostatic agents according to phenotypic manifestations of correlations (magnetic fluid effect – reactive response) are evidence of the individual peculiarities of free radicals formation in cells and development of oxidative stress. The indicated phenomenon of selective reactive changes in cells by effect of magnetic fluid is necessary to take into account in development of systems of directed transport of antitumor drugs.
| Published in | Cancer Research Journal (Volume 1, Issue 1) |
| DOI | 10.11648/j.crj.20130101.12 |
| Page(s) | 7-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2013. Published by Science Publishing Group |
MCF-7 Cells, Nanoparticles of Magnetic Fluid, Drug Resistance, Cytotoxic Effects, Adhesion, Invasion, Proliferative Activity, Free Radical Processes, Oxidative Stress, Lipids
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APA Style
Lukianova N Yu., Naleskina L A., Bezdenezhnykh N O., Kunskaya L M., Demash D V., et al. (2013). Reactive Changes of Cytophysiological Properties, Molecular-Biological Profile and Functional Metabolic Status of Cells in Vitro with Different Sensitivity to Cytostatic Agents Under the Influence of Magnetic Fluid. Cancer Research Journal, 1(1), 7-14. https://doi.org/10.11648/j.crj.20130101.12
ACS Style
Lukianova N Yu.; Naleskina L A.; Bezdenezhnykh N O.; Kunskaya L M.; Demash D V., et al. Reactive Changes of Cytophysiological Properties, Molecular-Biological Profile and Functional Metabolic Status of Cells in Vitro with Different Sensitivity to Cytostatic Agents Under the Influence of Magnetic Fluid. Cancer Res. J. 2013, 1(1), 7-14. doi: 10.11648/j.crj.20130101.12
AMA Style
Lukianova N Yu., Naleskina L A., Bezdenezhnykh N O., Kunskaya L M., Demash D V., et al. Reactive Changes of Cytophysiological Properties, Molecular-Biological Profile and Functional Metabolic Status of Cells in Vitro with Different Sensitivity to Cytostatic Agents Under the Influence of Magnetic Fluid. Cancer Res J. 2013;1(1):7-14. doi: 10.11648/j.crj.20130101.12
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Download@article{10.11648/j.crj.20130101.12,
author = {Lukianova N Yu. and Naleskina L A. and Bezdenezhnykh N O. and Kunskaya L M. and Demash D V. and Yanish Yu V. and Todor I N. and Chekhun V F.},
title = {Reactive Changes of Cytophysiological Properties, Molecular-Biological Profile and Functional Metabolic Status of Cells in Vitro with Different Sensitivity to Cytostatic Agents Under the Influence of Magnetic Fluid},
journal = {Cancer Research Journal},
volume = {1},
number = {1},
pages = {7-14},
doi = {10.11648/j.crj.20130101.12},
url = {https://doi.org/10.11648/j.crj.20130101.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130101.12},
abstract = {The peculiarities of changes of phenotype properties in MCF-7 human breast cancer cells with different sensitivity to cytostatic agents under the influence of nanoparticles of magnetic fluid were studied. It is defined that the biggest manifestations of magnetic fluid effect both by its essence and direction are observed in cells of resistant MCF-7/Dox line and parental MCF-7/S line in comparison with MCF-7/CP (cisplatin-resistant cell line). In particular, these are more apparent cytotoxic effects and ability to colony-formation, increase of adhesive properties, decrease of invasiveness and proliferative activity, changes of surface charge density and electrokinetic potential as well as lipid composition of cells. The defined differences between MCF-7 cells with different sensitivity to cytostatic agents according to phenotypic manifestations of correlations (magnetic fluid effect – reactive response) are evidence of the individual peculiarities of free radicals formation in cells and development of oxidative stress. The indicated phenomenon of selective reactive changes in cells by effect of magnetic fluid is necessary to take into account in development of systems of directed transport of antitumor drugs.},
year = {2013}
}
TY - JOUR T1 - Reactive Changes of Cytophysiological Properties, Molecular-Biological Profile and Functional Metabolic Status of Cells in Vitro with Different Sensitivity to Cytostatic Agents Under the Influence of Magnetic Fluid AU - Lukianova N Yu. AU - Naleskina L A. AU - Bezdenezhnykh N O. AU - Kunskaya L M. AU - Demash D V. AU - Yanish Yu V. AU - Todor I N. AU - Chekhun V F. Y1 - 2013/06/10 PY - 2013 N1 - https://doi.org/10.11648/j.crj.20130101.12 DO - 10.11648/j.crj.20130101.12 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 7 EP - 14 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20130101.12 AB - The peculiarities of changes of phenotype properties in MCF-7 human breast cancer cells with different sensitivity to cytostatic agents under the influence of nanoparticles of magnetic fluid were studied. It is defined that the biggest manifestations of magnetic fluid effect both by its essence and direction are observed in cells of resistant MCF-7/Dox line and parental MCF-7/S line in comparison with MCF-7/CP (cisplatin-resistant cell line). In particular, these are more apparent cytotoxic effects and ability to colony-formation, increase of adhesive properties, decrease of invasiveness and proliferative activity, changes of surface charge density and electrokinetic potential as well as lipid composition of cells. The defined differences between MCF-7 cells with different sensitivity to cytostatic agents according to phenotypic manifestations of correlations (magnetic fluid effect – reactive response) are evidence of the individual peculiarities of free radicals formation in cells and development of oxidative stress. The indicated phenomenon of selective reactive changes in cells by effect of magnetic fluid is necessary to take into account in development of systems of directed transport of antitumor drugs. VL - 1 IS - 1 ER -
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