Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia

Weiting Wang; Chunhua Hao; Rui Zhang; Yinzhong Ma; Shuangyong Sun; Zhuanyou Zhao; Lida Tang

doi:doi:10.11648/j.cmr.20170603.14

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Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia

Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, Zhuanyou Zhao, Lida Tang

Published in Clinical Medicine Research (Volume 6, Issue 3)

Received: 21 February 2017 Accepted: 21 March 2017 Published: 10 April 2017

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Abstract

Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.

Published in	Clinical Medicine Research (Volume 6, Issue 3)
DOI	10.11648/j.cmr.20170603.14
Page(s)	80-85
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Experimental Methodology, Anesthetics, Myocardial Ischemia-Reperfusion, Inflammatory Factor

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Cite This Article

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APA Style

Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, et al. (2017). Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clinical Medicine Research, 6(3), 80-85. https://doi.org/10.11648/j.cmr.20170603.14

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ACS Style

Weiting Wang; Chunhua Hao; Rui Zhang; Yinzhong Ma; Shuangyong Sun, et al. Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clin. Med. Res. 2017, 6(3), 80-85. doi: 10.11648/j.cmr.20170603.14

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AMA Style

Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, et al. Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clin Med Res. 2017;6(3):80-85. doi: 10.11648/j.cmr.20170603.14

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@article{10.11648/j.cmr.20170603.14,
  author = {Weiting Wang and Chunhua Hao and Rui Zhang and Yinzhong Ma and Shuangyong Sun and Zhuanyou Zhao and Lida Tang},
  title = {Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {3},
  pages = {80-85},
  doi = {10.11648/j.cmr.20170603.14},
  url = {https://doi.org/10.11648/j.cmr.20170603.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170603.14},
  abstract = {Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.},
 year = {2017}
}

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TY  - JOUR
T1  - Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia
AU  - Weiting Wang
AU  - Chunhua Hao
AU  - Rui Zhang
AU  - Yinzhong Ma
AU  - Shuangyong Sun
AU  - Zhuanyou Zhao
AU  - Lida Tang
Y1  - 2017/04/10
PY  - 2017
N1  - https://doi.org/10.11648/j.cmr.20170603.14
DO  - 10.11648/j.cmr.20170603.14
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 80
EP  - 85
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20170603.14
AB  - Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.
VL  - 6
IS  - 3
ER  -

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Author Information

Weiting Wang

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Chunhua Hao

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Rui Zhang

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Yinzhong Ma

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Shuangyong Sun

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Zhuanyou Zhao

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China
Lida Tang

State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, China

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Plain Text BibTeX RIS

APA Style

Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, et al. (2017). Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clinical Medicine Research, 6(3), 80-85. https://doi.org/10.11648/j.cmr.20170603.14

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ACS Style

Weiting Wang; Chunhua Hao; Rui Zhang; Yinzhong Ma; Shuangyong Sun, et al. Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clin. Med. Res. 2017, 6(3), 80-85. doi: 10.11648/j.cmr.20170603.14

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AMA Style

Weiting Wang, Chunhua Hao, Rui Zhang, Yinzhong Ma, Shuangyong Sun, et al. Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia. Clin Med Res. 2017;6(3):80-85. doi: 10.11648/j.cmr.20170603.14

Copy | Download

@article{10.11648/j.cmr.20170603.14,
  author = {Weiting Wang and Chunhua Hao and Rui Zhang and Yinzhong Ma and Shuangyong Sun and Zhuanyou Zhao and Lida Tang},
  title = {Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {3},
  pages = {80-85},
  doi = {10.11648/j.cmr.20170603.14},
  url = {https://doi.org/10.11648/j.cmr.20170603.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170603.14},
  abstract = {Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Experimental Methodology of Inflammatory Factors Induced by Anaesthetics in Myocardial Ischemia
AU  - Weiting Wang
AU  - Chunhua Hao
AU  - Rui Zhang
AU  - Yinzhong Ma
AU  - Shuangyong Sun
AU  - Zhuanyou Zhao
AU  - Lida Tang
Y1  - 2017/04/10
PY  - 2017
N1  - https://doi.org/10.11648/j.cmr.20170603.14
DO  - 10.11648/j.cmr.20170603.14
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 80
EP  - 85
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20170603.14
AB  - Current evidence indicates that anesthetics produce important effects to protect myocardium against ischemia-reperfusion (I/R) injury. The imbalance between pro- and anti-inflammatory cytokines might contribute to the mechanism of progression of I/R injury. To investigate experimental methodology of inflammatory factors in myocardial I/R with anesthetics preconditioning. This paper discusses the methods from the several aspects, including animal species, methods for model preparation, patterns of common anesthetics intervention, and the results of the intervention inflammatory factors including TNF-α, IL-1, IL-6, IL-8, IL-10 together with nuclear transcription factor NF-kB which regulates inflammation were explored in I/R models. The results showed that anesthetics exerted the protective effects on the injury of ischemia reperfusion injury through the regulation of inflammatory factors.
VL  - 6
IS  - 3
ER  -

Copy | Download