Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study

I. P. Ivanova; I. M. Piskarev; S. V. Trofimova

doi:doi:10.11648/j.ajpc.20130202.13

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Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study

I. P. Ivanova, I. M. Piskarev, S. V. Trofimova

Published in American Journal of Physical Chemistry (Volume 2, Issue 2)

Published: 2 April 2013

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Abstract

Mechanism of initial stage lipid peroxidation with HO2• radicals was investigated. The source of radicals was electric spark discharge radiation on air, rate of radicals generation in sample was 1.2 106 M (l s)1. The kinetic model of process was developed, based on the classical chain oxidation theory. Some process characteristics was calculated by means of numerical solution the system 24 differential equations of chemical kinetics. Initial lipid concentration was taken equals 2 103 M/l. It was shown the unsaturated lipids concentration after 2 hours treatment to spark discharge decrease in ~ 2 times, whereas for saturated lipids decreasing is only 7%. The hydroperoxides production was calculated. The new diene conjugate appearance in treated to spark discharge sample at lipids concentration 2 103 M l1 and treatment time about 10 minutes can't be detected, and just having in sample diens are destroyed. According simulation results, diene conjugates content is increased during treatment to spark discharge radiation at large lipids concentration, having 2 double bonds, (~0.5 M l1). This result is confirmed in experiment with sunflower oil (69% linoleic acid). The dependence of dienes concentration in sample from properties (intensities) external irradiation is ambiguous.

Published in	American Journal of Physical Chemistry (Volume 2, Issue 2)
DOI	10.11648/j.ajpc.20130202.13
Page(s)	44-51
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Saturated And Unsaturated Fatty Acids, Diene Conjugates, Radicals Ho2•, Simulation

References

[1]	Yu.A .Vladimirov, A.I. Archakov. "Lipid peroxidation in biological membranes". Nauka. Moscow. 1972.
[2]	K.M. Schaich. "Lipid oxidation: theoretical aspects". 6th ed. John Wiley & Sons. New York.. pp. 269 – 355. 2005.
[3]	Fridman Alexander. "Plasma Chemistry". Cambridge Uni-versity Press, Cambridge. 2008.
[4]	I.M. Piskarev, I.P. Ivanova, S.V. Trofimova, N.A. Aristova. "Formatiom of Active Species in Spark Discharge and Their Possible Use". High Energy Chemistry. vol. 46. pp. 343 – 348. 2012.
[5]	I.P. Ivanova, S.V. Trofimova, N. Karpel Vel Leitner, N.A. Aristova, E.V. Arkhipova, O.E. Burkhina, V.A. Sysoeva, I.M. Piskarev. "The analysis of active products of spark dis-charge plasma radiation determining biological effects in tissue". Modern Technologies in Medicine.. No 2. pp. 12 – 18. 2012.
[6]	Piskarev I.M., Ivanova I.P., Trofimova S.V. "Chemical Effects of Self-Sustained Spark Discharge: Simulation of Process in a Liquid". High Energy Chemistry. Vol. 47. No 2. pp. 152 – 156. 2013.
[7]	B. Halliwell, S. Chirico. "Lipid peroxidation: its mechanism, measurement and significance". The American Journal of Clinical Nutrition. Vol. 57 (Suppl). pp. 715 – 724. 1993.
[8]	I.P. Ivanova, S.V. Trofimova, I.M. Piskarev, O.E. Burkhina, V.A. Sysoeva, N. Karpel Vel Leitner. "The study of biocidal mechanisms of spark discharge plasma radiation". Modern Technologies in Medicine. No 3. pp. 12 – 18. 2012.
[9]	V.I. Vedeneev, L.V. Gurvich, V.N. Kondrat'ev, V.A. Med-vedev, E.L. Frankevich. "Chemical Bonds Energies, Ioniza-tion Potentials and Electron Affinity". Handbook. Moscow. Ed. AN USSR. P. 88. 1962
[10]	Luo Yu-Ran. "Handbook of bond dissociation energies in organic compounds". CRC Press LLC. Boca Raton. London, New York, Washington. pp. 1 – 94. 2003.
[11]	S.V. Ermolin, I.P. Ivanova, D.I. Knyazev, S.V. Trofimova, I.M. Piskarev. "Mechanism of Water Luminescence upon Radiolysis under the Effect of Background Radiation". Rus-sian Journal of Physical Chemistry. vol. A. 86. No 6. pp. 1029 – 1032. 2012.
[12]	Yu.A. Shlyapnikov, S.G. Kiryushkin, A.P.Mar'in. "Anti-oxidative Stabilization of Polymers". CRC Press, Tay-lor&Francis Group, Boca Raton, London. pp. 1 – 246. 1996.
[13]	Handbook of Chemistry and Physics. Ed. David R. Lide. 78 Edition. CRC Press. Boca Raton. New York. 1997.
[14]	Scrimgeour Charlie. "Chemistry of Fatty Acids". Sixth Edi-tion. John Wiley & Sons. New York, pp. 1 – 49. 2005.
[15]	I.P. Ivanova, S.V. Trofimova, I.M. Piskarev, A.A. Ichetkina, O.E. Burkhina, V.A. Sysoeva. "The Influence of the Spark Discharge plasma Radiation on Protein's and Lipid's Mod-ification". Fundamental Research (Biological Science). No 1. pp. 572 – 576. 2013.

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APA Style

I. P. Ivanova, I. M. Piskarev, S. V. Trofimova. (2013). Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study. American Journal of Physical Chemistry, 2(2), 44-51. https://doi.org/10.11648/j.ajpc.20130202.13

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ACS Style

I. P. Ivanova; I. M. Piskarev; S. V. Trofimova. Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study. Am. J. Phys. Chem. 2013, 2(2), 44-51. doi: 10.11648/j.ajpc.20130202.13

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AMA Style

I. P. Ivanova, I. M. Piskarev, S. V. Trofimova. Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study. Am J Phys Chem. 2013;2(2):44-51. doi: 10.11648/j.ajpc.20130202.13

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@article{10.11648/j.ajpc.20130202.13,
  author = {I. P. Ivanova and I. M. Piskarev and S. V. Trofimova},
  title = {Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study},
  journal = {American Journal of Physical Chemistry},
  volume = {2},
  number = {2},
  pages = {44-51},
  doi = {10.11648/j.ajpc.20130202.13},
  url = {https://doi.org/10.11648/j.ajpc.20130202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpc.20130202.13},
  abstract = {Mechanism of initial stage lipid peroxidation with HO2• radicals was investigated. The source of radicals was electric spark discharge radiation on air, rate of radicals generation in sample was 1.2 106 M (l s)1. The kinetic model of process was developed, based on the classical chain oxidation theory. Some process characteristics was calculated by means of numerical solution the system 24 differential equations of chemical kinetics. Initial lipid concentration was taken equals 2 103 M/l. It was shown the unsaturated lipids concentration after 2 hours treatment to spark discharge decrease in ~ 2 times, whereas for saturated lipids decreasing is only 7%. The hydroperoxides production was calculated. The new diene conjugate appearance in treated to spark discharge sample at lipids concentration 2 103 M l1 and treatment time about 10 minutes can't be detected, and just having in sample diens are destroyed. According simulation results, diene conjugates content is increased during treatment to spark discharge radiation at large lipids concentration, having 2 double bonds, (~0.5 M l1). This result is confirmed in experiment with sunflower oil (69% linoleic acid). The dependence of dienes concentration in sample from properties (intensities) external irradiation is ambiguous.},
 year = {2013}
}

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TY - JOUR
T1 - Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study
AU - I. P. Ivanova
AU - I. M. Piskarev
AU - S. V. Trofimova
Y1 - 2013/04/02
PY - 2013
N1 - https://doi.org/10.11648/j.ajpc.20130202.13
DO - 10.11648/j.ajpc.20130202.13
T2 - American Journal of Physical Chemistry
JF - American Journal of Physical Chemistry
JO - American Journal of Physical Chemistry
SP - 44
EP - 51
PB - Science Publishing Group
SN - 2327-2449
UR - https://doi.org/10.11648/j.ajpc.20130202.13
AB - Mechanism of initial stage lipid peroxidation with HO2• radicals was investigated. The source of radicals was electric spark discharge radiation on air, rate of radicals generation in sample was 1.2 106 M (l s)1. The kinetic model of process was developed, based on the classical chain oxidation theory. Some process characteristics was calculated by means of numerical solution the system 24 differential equations of chemical kinetics. Initial lipid concentration was taken equals 2 103 M/l. It was shown the unsaturated lipids concentration after 2 hours treatment to spark discharge decrease in ~ 2 times, whereas for saturated lipids decreasing is only 7%. The hydroperoxides production was calculated. The new diene conjugate appearance in treated to spark discharge sample at lipids concentration 2 103 M l1 and treatment time about 10 minutes can't be detected, and just having in sample diens are destroyed. According simulation results, diene conjugates content is increased during treatment to spark discharge radiation at large lipids concentration, having 2 double bonds, (~0.5 M l1). This result is confirmed in experiment with sunflower oil (69% linoleic acid). The dependence of dienes concentration in sample from properties (intensities) external irradiation is ambiguous.
VL - 2
IS - 2
ER -

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Author Information

I. P. Ivanova

Fundamental Research Laboratory of Physicochemical Studies, Scientific Research Institute of Applied Fundamental Medicine, Nizhny Novgorod State Medical Academy. (NNSMA), Minin and Pojarsky square, 10/1, 603005, Nizhny Novgorod, Russian Federation
I. M. Piskarev

D.V. Skobeltsin Institute of Nuclear Physics M.V. Lomonosov Moscow State University (NPI MSU), 1(2), Leninskie gory, Moscow, 119234, Russian Federation
S. V. Trofimova

Fundamental Research Laboratory of Physicochemical Studies, Scientific Research Institute of Applied Fundamental Medicine, Nizhny Novgorod State Medical Academy. (NNSMA), Minin and Pojarsky square, 10/1, 603005, Nizhny Novgorod, Russian Federation

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Plain Text BibTeX RIS

APA Style

I. P. Ivanova, I. M. Piskarev, S. V. Trofimova. (2013). Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study. American Journal of Physical Chemistry, 2(2), 44-51. https://doi.org/10.11648/j.ajpc.20130202.13

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ACS Style

I. P. Ivanova; I. M. Piskarev; S. V. Trofimova. Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study. Am. J. Phys. Chem. 2013, 2(2), 44-51. doi: 10.11648/j.ajpc.20130202.13

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AMA Style

I. P. Ivanova, I. M. Piskarev, S. V. Trofimova. Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study. Am J Phys Chem. 2013;2(2):44-51. doi: 10.11648/j.ajpc.20130202.13

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@article{10.11648/j.ajpc.20130202.13,
  author = {I. P. Ivanova and I. M. Piskarev and S. V. Trofimova},
  title = {Initial Stage of Lipid Peroxidation with HO2• Radicals. Kinetic Study},
  journal = {American Journal of Physical Chemistry},
  volume = {2},
  number = {2},
  pages = {44-51},
  doi = {10.11648/j.ajpc.20130202.13},
  url = {https://doi.org/10.11648/j.ajpc.20130202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpc.20130202.13},
  abstract = {Mechanism of initial stage lipid peroxidation with HO2• radicals was investigated. The source of radicals was electric spark discharge radiation on air, rate of radicals generation in sample was 1.2 106 M (l s)1. The kinetic model of process was developed, based on the classical chain oxidation theory. Some process characteristics was calculated by means of numerical solution the system 24 differential equations of chemical kinetics. Initial lipid concentration was taken equals 2 103 M/l. It was shown the unsaturated lipids concentration after 2 hours treatment to spark discharge decrease in ~ 2 times, whereas for saturated lipids decreasing is only 7%. The hydroperoxides production was calculated. The new diene conjugate appearance in treated to spark discharge sample at lipids concentration 2 103 M l1 and treatment time about 10 minutes can't be detected, and just having in sample diens are destroyed. According simulation results, diene conjugates content is increased during treatment to spark discharge radiation at large lipids concentration, having 2 double bonds, (~0.5 M l1). This result is confirmed in experiment with sunflower oil (69% linoleic acid). The dependence of dienes concentration in sample from properties (intensities) external irradiation is ambiguous.},
 year = {2013}
}

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