Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection

Oksana Sulaieva; Natalia Obraztsova

doi:doi:10.11648/j.ajcem.20140202.13

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Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection

Oksana Sulaieva, Natalia Obraztsova

Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 2)

Received: 18 March 2014 Accepted: 9 April 2014 Published: 20 April 2014

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Abstract

Objective: In this review we focused on understanding the cause-and-effect relationships of gastroduodenal pathology aiming to clarify the role of vagus nerve. Results: The spectrum of vagus nerve biological effects in gastroduodenal area is related to its numerous targets and a wide range of its receptors. A variety of vagus nerve effects are related to the broad expression of cholinergic receptors on the target cells: smooth muscle cells, covering and glandular epithelium of stomach and duodenum, myofibroblasts and mast cells, vascular endothelium, intramural ganglion neurons, endocrine cells, platelets and blood leukocytes. In this paper, we discussed the following issues: 1) role of sensory nerve endings in the vagal reflex regulation; 2) impact of gastrin and leptin on vagal afferentation; 3) targets of vagus efferent nerves; 4) the role of acetylcholine in regulation of functional activity of oxyntic cells; 5) relationship of vagus efferents with enteroendocrine cells; 6) the role of vagus nerve in realization of compensatory and adaptive reactions in gastroduodenal area. Conclusion: Vagus nerve is one of the key regulators of mucosal activity and blood supply, modulating adaptive reactions and maintaining the gastrointestinal barrier

Published in	American Journal of Clinical and Experimental Medicine (Volume 2, Issue 2)
DOI	10.11648/j.ajcem.20140202.13
Page(s)	22-27
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Gastroduodenal Area, Vagus Nerve, Afferent and Efferent Nerves

References

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APA Style

Oksana Sulaieva, Natalia Obraztsova. (2014). Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection. American Journal of Clinical and Experimental Medicine, 2(2), 22-27. https://doi.org/10.11648/j.ajcem.20140202.13

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ACS Style

Oksana Sulaieva; Natalia Obraztsova. Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection. Am. J. Clin. Exp. Med. 2014, 2(2), 22-27. doi: 10.11648/j.ajcem.20140202.13

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AMA Style

Oksana Sulaieva, Natalia Obraztsova. Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection. Am J Clin Exp Med. 2014;2(2):22-27. doi: 10.11648/j.ajcem.20140202.13

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@article{10.11648/j.ajcem.20140202.13,
  author = {Oksana Sulaieva and Natalia Obraztsova},
  title = {Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {2},
  pages = {22-27},
  doi = {10.11648/j.ajcem.20140202.13},
  url = {https://doi.org/10.11648/j.ajcem.20140202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140202.13},
  abstract = {Objective: In this review we focused on understanding the cause-and-effect relationships of gastroduodenal pathology aiming to clarify the role of vagus nerve. Results: The spectrum of vagus nerve biological effects in gastroduodenal area is related to its numerous targets and a wide range of its receptors. A variety of vagus nerve effects are related to the broad expression of cholinergic receptors on the target cells: smooth muscle cells, covering and glandular epithelium of stomach and duodenum, myofibroblasts and mast cells, vascular endothelium, intramural ganglion neurons, endocrine cells, platelets and blood leukocytes. In this paper, we discussed the following issues: 1) role of sensory nerve endings in the vagal reflex regulation; 2) impact of gastrin and leptin on vagal afferentation; 3) targets of vagus efferent nerves; 4) the role of acetylcholine in regulation of functional activity of oxyntic cells; 5) relationship of vagus efferents with enteroendocrine cells; 6) the role of vagus nerve in realization of compensatory and adaptive reactions in gastroduodenal area. Conclusion: Vagus nerve is one of the key regulators of mucosal activity and blood supply, modulating adaptive reactions and maintaining the gastrointestinal barrier},
 year = {2014}
}

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TY  - JOUR
T1  - Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection
AU  - Oksana Sulaieva
AU  - Natalia Obraztsova
Y1  - 2014/04/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140202.13
DO  - 10.11648/j.ajcem.20140202.13
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 22
EP  - 27
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140202.13
AB  - Objective: In this review we focused on understanding the cause-and-effect relationships of gastroduodenal pathology aiming to clarify the role of vagus nerve. Results: The spectrum of vagus nerve biological effects in gastroduodenal area is related to its numerous targets and a wide range of its receptors. A variety of vagus nerve effects are related to the broad expression of cholinergic receptors on the target cells: smooth muscle cells, covering and glandular epithelium of stomach and duodenum, myofibroblasts and mast cells, vascular endothelium, intramural ganglion neurons, endocrine cells, platelets and blood leukocytes. In this paper, we discussed the following issues: 1) role of sensory nerve endings in the vagal reflex regulation; 2) impact of gastrin and leptin on vagal afferentation; 3) targets of vagus efferent nerves; 4) the role of acetylcholine in regulation of functional activity of oxyntic cells; 5) relationship of vagus efferents with enteroendocrine cells; 6) the role of vagus nerve in realization of compensatory and adaptive reactions in gastroduodenal area. Conclusion: Vagus nerve is one of the key regulators of mucosal activity and blood supply, modulating adaptive reactions and maintaining the gastrointestinal barrier
VL  - 2
IS  - 2
ER  -

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Author Information

Oksana Sulaieva

Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine
Natalia Obraztsova

Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine

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Plain Text BibTeX RIS

APA Style

Oksana Sulaieva, Natalia Obraztsova. (2014). Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection. American Journal of Clinical and Experimental Medicine, 2(2), 22-27. https://doi.org/10.11648/j.ajcem.20140202.13

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ACS Style

Oksana Sulaieva; Natalia Obraztsova. Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection. Am. J. Clin. Exp. Med. 2014, 2(2), 22-27. doi: 10.11648/j.ajcem.20140202.13

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AMA Style

Oksana Sulaieva, Natalia Obraztsova. Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection. Am J Clin Exp Med. 2014;2(2):22-27. doi: 10.11648/j.ajcem.20140202.13

Copy | Download

@article{10.11648/j.ajcem.20140202.13,
  author = {Oksana Sulaieva and Natalia Obraztsova},
  title = {Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {2},
  pages = {22-27},
  doi = {10.11648/j.ajcem.20140202.13},
  url = {https://doi.org/10.11648/j.ajcem.20140202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140202.13},
  abstract = {Objective: In this review we focused on understanding the cause-and-effect relationships of gastroduodenal pathology aiming to clarify the role of vagus nerve. Results: The spectrum of vagus nerve biological effects in gastroduodenal area is related to its numerous targets and a wide range of its receptors. A variety of vagus nerve effects are related to the broad expression of cholinergic receptors on the target cells: smooth muscle cells, covering and glandular epithelium of stomach and duodenum, myofibroblasts and mast cells, vascular endothelium, intramural ganglion neurons, endocrine cells, platelets and blood leukocytes. In this paper, we discussed the following issues: 1) role of sensory nerve endings in the vagal reflex regulation; 2) impact of gastrin and leptin on vagal afferentation; 3) targets of vagus efferent nerves; 4) the role of acetylcholine in regulation of functional activity of oxyntic cells; 5) relationship of vagus efferents with enteroendocrine cells; 6) the role of vagus nerve in realization of compensatory and adaptive reactions in gastroduodenal area. Conclusion: Vagus nerve is one of the key regulators of mucosal activity and blood supply, modulating adaptive reactions and maintaining the gastrointestinal barrier},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Role of Vagus Nerve in Gastroduodenal Adaptation and Cytoprotection
AU  - Oksana Sulaieva
AU  - Natalia Obraztsova
Y1  - 2014/04/20
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140202.13
DO  - 10.11648/j.ajcem.20140202.13
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 22
EP  - 27
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140202.13
AB  - Objective: In this review we focused on understanding the cause-and-effect relationships of gastroduodenal pathology aiming to clarify the role of vagus nerve. Results: The spectrum of vagus nerve biological effects in gastroduodenal area is related to its numerous targets and a wide range of its receptors. A variety of vagus nerve effects are related to the broad expression of cholinergic receptors on the target cells: smooth muscle cells, covering and glandular epithelium of stomach and duodenum, myofibroblasts and mast cells, vascular endothelium, intramural ganglion neurons, endocrine cells, platelets and blood leukocytes. In this paper, we discussed the following issues: 1) role of sensory nerve endings in the vagal reflex regulation; 2) impact of gastrin and leptin on vagal afferentation; 3) targets of vagus efferent nerves; 4) the role of acetylcholine in regulation of functional activity of oxyntic cells; 5) relationship of vagus efferents with enteroendocrine cells; 6) the role of vagus nerve in realization of compensatory and adaptive reactions in gastroduodenal area. Conclusion: Vagus nerve is one of the key regulators of mucosal activity and blood supply, modulating adaptive reactions and maintaining the gastrointestinal barrier
VL  - 2
IS  - 2
ER  -

Copy | Download